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Tuesday, April 20, 2021

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Hydroxychloroquine- Some Unsaid Implications

Hydroxychloroquine is an inexpensive and easily available drug. However, its demand has risen dramatically ever since it was named as a possible treatment for COVID-19

Hydroxychloroquine is very similar to Chloroquine, one of the oldest and best-known anti-malarial drugs. With US President Donald Trump pushing for its usage, there’s excitement about a potential new treatment for the coronavirus pandemic. Reports from China suggested that chloroquine could inhibit SARS-CoV-2 in vitro, and showed apparent efficacy in treating COVID-19 in humans. A small non-randomized trial in France also found hydroxychloroquine to be a promising potential treatment.

The findings have prompted many, including US President Donald Trump, to tout hydroxychloroquine as a game-changer in the fight coronavirus, which has infected over 1.3 million people across more than 180 countries. Scientists, however, say more testing is needed before it’s proven safe and effective against the virus.

What is the drug hydroxychloroquine used for?

Hydroxychloroquine (HCQ) is a medication used to prevent and treat malaria. Other uses include treatment of rheumatoid arthritis and lupus erythematosus. It is also being studied as an experimental treatment for Covid-19.

Has it been approved for use in the case of coronavirus?

On March 28, 2020, the Food and Drug Administration (FDA) gave an emergency approval to the US government to distribute millions of doses of anti-malarial drugs to hospitals across the country, saying it is worth the risk of trying unproven treatments to slow the progression of the disease caused by the novel coronavirus in seriously ill patients. However, FDA’s emergency authorization does not cover the longer-term use of the drugs to prevent the coronavirus infection.

Demand for hydroxychloroquine

Hydroxychloroquine is an inexpensive and easily available drug. However, its demand has risen dramatically ever since it was named as a possible treatment for Covid-19. India manufactures it in large quantities. On Saturday, the government banned the export of the drug “without any exception”. The order came even as the number of positive cases of Covid-19 spiked in the country.

On Tuesday, however, the government partially lifted the ban, paving the way for its supply to the US and several other countries hit hard by the coronavirus pandemic.

Government officials said India would export hydroxychloroquine and paracetamol on a case-by-case basis to the countries which have already placed orders for them after meeting the domestic requirements.

The decision to partially lift the ban on hydroxychloroquine came to the fore hours after US President Donald Trump warned of retaliation if India does not heed to his request to supply the drug, cited by him as a viable therapeutic solution to fight coronavirus infection.

According to news agency PTI, India is said to have received requests from at least 20 countries including its immediate neighbors Sri Lanka and Nepal for the supply of hydroxychloroquine.

Coronavirus impact

For most people, the virus causes mild or moderate symptoms, such as fever and cough that clear up in two to three weeks. For some, especially older adults and people with existing health problems, it can cause more severe illness, including pneumonia, and death. So far, nearly 75,000 people across the globe have died from the disease.

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